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All you need to know about CBD oil

There is a great deal of confusing information floating about the internet regarding Cannabidiol or CBD Oil. The following will make CBD Oil far less confusing to you and expose you to the basics.

What is known as Cannabidiol or (CBD)

CBD is a natural substance that has most recently become the topic of conversations nationwide for a multitude of reasons. This [relatively] new food supplement is currently being researched and has garnered initial results that appear to be quite promising. Due to the fact that the supplement is still being researched, there remains a great deal of confusion regarding it.

cbd oil

 

Most recently, the oil has become very popular as well as accepted as a means of relaxation. It does need to be noted that due to the newness of CBD, there are a lot of gaps in what is actually known about the effects it can and may have on users. Transversely, it can be stated with confidence that CBD is legal and safe for use while its full benefits are up for debate.

Benefits of CBD

There have been a substantial number of people who have reported success when utilizing CBD in regards to relaxation and calm. As a chemical substance [strictly], the oil has antioxidants that are best described as strong. Unfortunately, this is a fact that has been virtually ignored by the broad spectrum of the industry of food supplements.

 

What is CBD in 60 seconds

Where Does CBD Come from?

CBD Oil is separated and extracted from specified variants of the cannabis plant, most commonly known as hemp. CBD is among the 85 chemical substances that are commonly referred to as cannabinoids (which are all found within cannabis). Additionally, the oil is the second most abundant compound found in hemp and traditionally represents upwards of 40% of the plant’s extracts.

The most abundant component THC. THC is illegal and is a highly intoxicating substance that is why marijuana users become “high”. It does need to be dually noted that CBD and THC are completed isolated from one another and CBD will NOT cause any form of intoxication. Unfortunately, CBD is often confused with THC and that alone has created a stigma around it.

Is CBD Legal?

Globally, CBD is legal with one exception; within the borders of Canada, CBD Oil is considered to be a controlled substance.

Terms to Understand Regarding CBD Oil

In regards to CBD Oil, there are a number of terms that can be confusing. The following definitions are intended to remove the confusion.

Cannabis

Cannabis is a flowering plant that has a trio of variations that is Indica, Sativa and ruderalis. It has a number of medicinal and industrial applications in addition to being used for recreational purposes.

Hemp

This refers to high growing variants of cannabis that are grown specifically for seeds, oil and fiber. The listed are generally refined into a number of products that are inclusive of the following: hemp oil, fuel, rope, paper, pulp, cloth, resin and wax.

Cannabinoids

A highly diversified chemical family that includes artificially and naturally created substances. Some are considered to be illegal while other provide properties known to sooth and calm. Moreover, the effects of cannabinoids are very wide ranging.

CBD

Also known as Cannadidiol, it is a substance that occurs naturally. It is the second most abundant component of cannabis. CBD is safe to consumer as well as legal, but is often confused with THC.

THC

This is the most abundant component of Cannabis as well as a psychoactive cannabinoid that is quite strong. THC is STRICTLY regulated due to it being the reason as to how marijuana users “get high”.

Psychoactive

This is any chemical substance that is able to enter the brain via the bloodstream and affect [directly] the central nervous system. Many of these substances have medicinal applications such as psychiatric drugs, anesthetics and more). Some psychoactive substances are used solely for recreation and are accompanied by addiction and dangerous side effects.

Intoxicating

A substance that will cause a person to alter their behavior and lose control of their faculties. Virtually all illegal drugs contain properties that are intoxicating, although most often intoxication is [generally] attributed to alcohol consumption alone.

What is the Difference Between THC and CBD?

The two most abundant cannabinoids that occur naturally within hemp are tetrahydrocannabinol (THC) and Cannabidiol (CBD). Both THC and CBD are classified as phytocannabinoids and interact with specified cells [predominately] within the brain, but in other organs as well. Additionally, both of the substances present a wide variant of applications while being quite similar on a molecular level.

With that being said, the chemical properties of THC and CBD vary great enough that one is legal and the other is not. THC is classified as a psychotropic drug that is under stringent control via federal authorities and is viewed as illegal for recreational use. CBD is safe for use and is widely regarded as legal, globally.

How Does CBD Work?

CBD is quite unique when compared to other cannabinoids due to the fact that this substance does NOT seem to have direct interaction with the CB2 or CB1 receptors. That leaves many to wonder as to if there is no interaction with receptors then how does it function.

Traditionally, CBD has a principally low potential for binding with the receptors for CB1 and CB2. Therefore, it acts more as an antagonist of the agonist of the receptors. Or, may be CBD is able to keep receptors working at their optimum capacity. Additionally, it is able to assist the function of other cannabinoids that include the endocannabinoids of the body itself.

What Are the Effects of CBD?

In order to properly understand the function of CBD Oil within the body, how receptors interact with other chemical compounds must be explained. That explanation begins with the following definitions:

• Antagonists – The comprehensive opposite of agonists. They impede and diminish the functionality of receptors.

• Agonists – These are chemicals that bind to receptors while stimulating them in order to yield a biological response.

• Inverse Agonists – These chemicals are able to bind to the same receptors as agonists. The result of inverse agonists is the polar opposite of agonists.

It has been found that CBD has a variety of indirect interactions with the body’s endocannabinoid system. Some of the interactions have been noted as being a surprise to scientists and, therefore, continue to be researched to date. The most notable of the functions of CBD are as follows:

• Delivers an effective increase the density of CB1 receptors. This increase provides amplified effects in regards to cannabinoids that bind to the stated receptors.

• Within the brain, CBD acts as 5 HT1 which is a receptor agonist. Basically, CBD Oil has an effect that is both soothing and calming which is equivalent to a handful of powerful analgesics. Do note that, unlike analgesics, CBD does not have any side effects.

• In regards to CB2 receptors, CBD Oil is able to act as an inverse agonist allowing it lessen the impact of cannabinoids that traditionally make the receptors far less responsive.

• CBD is an antagonist for the putative receptor, GPR55. This is a component of the body’s endocannabinoid system that is currently being researched itself. It has been suggested that the putative receptor may very well be a third variant of a cannabinoid receptor.

Although the effects of CBD listed above are the most observed and have consistently been well explained; scientist remain fairly unclear as to how the effect occur. According to a number of scientists researching CBD, a plausible explanation is that the GPR55 receptor plays an integral role. Another explanation is that there are more synergistic and indirect effects that are awaiting discovery that will unlock how CBD oil is able to provide its effects.

CBD Oil from Industrial Hemp Oil vs. CBD Oil from Medical Marijuana: What is the Difference?

There are a number of people that understand that Cannabidiol from industrial hemp. Most people worldwide only know that CBD can be garnered from medical grade marijuana. Both are accurate forms of garnering CBD, but the question that lingers is, “What is the difference is CBD being produced from industrial hemp or medical marijuana?”

From there, may consumers also wonder if one option is better than the other, or if the properties or effects differ depending on how CBD oil is produced. The following will offer clarity for these queries and more.

Cannabidiol is Cannabidiol Whether from Hemp or Marijuana

The following should always be kept firmly in mind…regardless of the chemical composition of CBD, it remains unaltered regardless of the precise plant that produces it. Furthermore, keep in mind the definition of Cannabidiol is as follows:

At least one of 113 active cannabinoids have been identified in cannabis. This substance acts as a phytocannabinoid which accounts for upwards of 40% of the cannabis plant extract.

Different explanations of CBD oil have no place here do to the fact that the substance is simply what it is. A singular difference within the molecular composition would result in the substance no longer being CBD Oil. Basically, this is purely chemistry leaving absolutely NO ROOM for any amount of ambiguity.

What is inside Cannabidiol Oil?

It has been well established that CBD naturally occurs regardless to whether it is cultivated from industrial hemp or medical grade marijuana. With that being said, CBD Oil is a mixture of a variant of natural substances that have been derived the plant of cannabis.

Hemp oil production tends to involve the extraction of fatty acid from cannabis’s stalks. Inside the fatty acids, fat-soluble substances are found. Cannabinoids are fat soluble and as they are extracted from the plant, they are able to be dissolved into the oil itself.

For example, a high CBD hemp oil product that is produced from industrial hemp would have a CBD concentration of between 18 to 24%. This would result in 18 to 24% parts of CBD being dissolved into the oil that would be comprised of additional substances. Basically, fatty acid substances, along with hemp oil extracts would be combined with 18 to 24% pure CBD.

Industrial Hemp CBD Oil vs. Medical Grade Marijuana CBD Oil

Regardless of where CBD is extracted from, it is still CBD. CBD Oil, on the other hand is not the same when garnered from industrial hemp as it is when from medical marijuana. The most prominent difference between the two versions of CBD Oil is that the variant garnered from medical marijuana will contain varied amounts of the substance THC. Due to this fact, CBD made from medical grade marijuana is globally classified as drug under Schedule 1 and is illegal in most areas within the Unites States.

In regards to industrial hemp, it is high in CBD naturally and only trace amounts of THC exist within it. Therefore, the hemp oil that is produced through the use of industrial hemp is non-psychotropic as well as safe and legal. In addition, this type of oil is quite different from that which is created by the extraction of fatty acids from cannabis plants grown for the purpose of soothing.

Other than the difference in regards to the concentrations of THC, the duo of oil types also contains variant amounts of additional cannabinoids. The additional cannabinoids occur in percentages that are far smaller in regards to the overall volume when compared to percentages of THC and CBD within the oils.

This is why when considering purchasing CBD Oil, it is far better and safer to opt for CBD Oil that has produced via industrial hemp. There is virtually no THC within the oil and industrial hemp is naturally rich in CBD.

The Benefits of CBD Oil

Through research, that is currently ongoing, it has been determined that CBD Oil is an effective benefit for some ailments. Patients have received relief as well as an opportunity to live a more normalized lifestyle do the introduction of CBD Oil into the medical regiment.

Epilepsy

Dravet’s syndrome, which is a type of epilepsy has consistently be highly difficult to treat and intractable. It is very serious and tends to have its onset at infancy. The initial seizures associated with the syndrome are generally prolonged by the age of 2, additional kinds of seizures start to develop. A variety of anecdotal and high profile reports have created a thriving interest in the use of Cannabidiol as a viable treatment for Dravet’s syndrome.

Currently, hemp/cannabis extract supplements, such as Charlotte’s Web Hemp Extract that are being marketed as an effective treatment for the syndrome. Two years ago, there was a review that surfaced claiming that Cannabidiol was an optimal benefit for patients (in general) suffering from epilepsy. Within the review, it was stated that there was not an established plan of action as well as a lack of evidence that is high quality that precluded the drawn conclusions.

A more recent review that was released this year within the Journal of Medicine in New England noted that for the past three years’, an ample amount of data was gathered regarding patients suffering from both Lennox-Gastaut syndrome and Dravet’s syndrome. The study that was being reviewed involved a total of 137 patients that were treated with Epidiolex (which contained CBD Oil) and seizure were shown to reduce by a median of 54%.

Psychosis

Tentative evidence has been uncovered proclaiming that CBD Oil has the ability to present an anti-psychotic effect on patients. Even with that being said, it must be dually noted that the research within this particular area has been quite limited (thus far).

What is a Safe Dosage of CBD Oil?

According to an array of studies, it has been determined that CBD Oil is safe for consumption of doses of upwards of either 30mg or 1500mg per day. The studies that this information was gathered from were multiple in number but small in comparison to other drug/substance studies.

Pharmacokinetic Interactions

Preclinical evidence has surfaced indicating that THC clearance can be reduced via the use of Cannabidiol. This causes a modest increase the plasma concentrations of THC which can result in heightened amounts of THC being made available to receptors within the body. Even with that being said, there is no evidence that is available that contends that there is any significant amount of an effect of CBD Oil of the plasma levels of THC.

Pharmaceutical Preparations

The medication Nabiximols (which has the tradename of Sativex) is a mist that is aerosolized for administration orally for the alleviation of the pain most commonly related to multiple sclerosis syndrome. It contains a virtual ration of 1:1 ratio of both THC and CBD and was approved eleven years ago in Canada. Last year, Epidiolex (which contains the active ingredient as Cannabidiol pharmaceutically) received the status of orphan drug within US to be used for treatment of Dravet’s syndrome. This particular drug is formulated as oil form of CBD and contains cannabis plant extract. This drug is currently undergoing clinical trial for epilepsy syndromes that are refractory.

What Makes CBD Oil Different?

In the current market of supplements and medications there are countless amounts for consumers to choose from and it can be a daunting determining what is best for you. Even with CBD Oil being relatively new to the market, this oil is able to stand out as an ideal method for soothing and calm. Additionally, scientists that are researching CBD Oil are remaining open to a wider range of applications that will plausibly be uncovered within the near future.

For a number of people, CBD Oil based products are increasing becoming a relaxing addition to their daily regiments. It does need to be kept in mind that every person has differing needs, therefore all are encouraged to research any product thoroughly before consuming it.

Legal Status of CBD Oil

Before purchasing Cannabidiol, you do need to note that it is not currently scheduled via Psychotropic Substances Convention. Also, CBD Oil does not induce the “high” feeling that is associated with the THC that is found abundantly in marijuana. In regards to the legal understanding and landscape, you will need to understand that ONLY CBD Oil derived from industrial hemp is legal within the United States. CBD Oil that is produced from medical grade marijuana contains variant levels of THC making it illegal throughout the vast majority of the United States.

Numerous ‘medical marijuana’ strains have been found to have a substantial assortment with the proportions of CBD-to-THC and may have other cannabinoids that are not psychotropic. Bu, it is only the quantity of 9 THC that allows legal determination chemically as to whether the plant extract used for getting CBD may be regarded as hemp or marijuana.

Most of the psychotropic marijuana is derived from the flower of the genus cannabis. Industrial hemp is derived from any part of the genus cannabis plant, and may contain a 9 THC CBD concentration of a maximum of 3 tenths of single percent based on dry weight. Certain canons may be needed for the legal production and growth of hemp.

The farmers in Kentucky are invited by Industrial Hemp Research Program, founded by James Comer, the current commissioner of agriculture.

The US Drug Enforcement Administration or DEA, have shown some leniency regarding some regulations for those performing clinical trials on CBD that are approved by FDA.

 

Western Europe allows legal farming of many varieties of industrial hemp, including “Fedora 17” that shows a cannabinoid profile on a consistent basis of around one percent cannabidiol and THC less than 0.1%.[67]

 

In Conclusion

Unlike most other cannabinoids and their functionality, CBD Oil is able to mildly interact with receptors of cannabinoid themselves. This allows the oil to either cease the effects of what is causing receptors work far less efficiently or to allow additional cannabinoids to become better absorbed.

It has been widely speculated that the indirect nature of Cannabidiol has made is somewhat difficult for research scientists to pinpoint the precise effects thus far. Yet, many of the positive effects of the phytocannabinoid are currently being studied thoroughly by scientists across that country.

Moreover, be certain, just as with any medication or supplement, to consult your primary care physician before adding CBD to your regiment. Also, when researching specific CBD isolate  products, be certain to verify that it will not negatively interact with any current medications that you are taking.